Abstract
Inflammatory bowel disease (IBD) is a commonly relapsing and relapsing seditious disease of the small and large intestine. IBD includes ulcerative colitis (UC) and Crohn's disease (CD) and is the leading cause of the spread of colon cancer known as cancer-associated colitis (CAC). A bead-based drug delivery system targeting the oral colon containing metronidazole-loaded chitosan beads coated with eudragit S-100 was prepared, optimized, and characterized. Metronidazole-loaded colon-targeted microspheres were prepared with a simple emulsion system followed by a cross-linking system. The variable drug polymer ratio was optimized for based on particle size, capture efficiency, further optimized F2 composition was coated with Eudragit S-100. The prepared microspheres were stable spherical particles and showed favorable release profiles in the simulated colonic fluid.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmaceutical Sciences and Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
