Abstract
Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different super disintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing super disintegrants was more as compared to FDTs without super disintegrant and it was found to be highest (98% drug release after 30min)with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.
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