Abstract
Objective: The aim of the present work was to formulate silk fibroin (SF) nanospheres (NS’s) for drug delivery application. The current study was designed to advance the water solubility and bio-availability of telmisartan by nanoprecipitation method.Methods: SF NS’s loaded with TS were prepared by nanoprecipitation method. The drug was dissolved in aqueous solution of SF by using acetone as a non-solvent. The prepared NS’s were then characterized by FTIR, X-ray diffraction and zeta potential, and were evaluated for its, surface morphology, %drug content, encapsulation efficiency and in vitro drug release.Results: The evaluation results of SF NS’s loaded of TS showed 74.22±0.17 % entrapment efficiency, 35.21±0.02 % of drug loading, and-4.9 mV to-13.6 mV of zeta potential due to the proper bounding of TS with the β-sheets of SF, the particle size reported was within the size range of 160-186 nm having smooth surface and were spherical in shape. The SFNS’s pattern switched from random coil to β-sheet formation on treating with acetone. FTIR and DSC studies marked no such inter-molecular interactions between SF and drug molecules. The % cumulative in vitro drug release from SF NS’s exhibited quick burst release. The in vitro cumulative drug release of SF NS’s of TS it was found that about 74% of the drug was released within 8 h and about 96% of drug released at 24 hr. The rate of drug release increased with the increase in SF ratio.Conclusion: It is believed that these SF NS’s will find potential applications in drug delivery release as drug carriers, especially poor water-soluble drugs. All these results proposed that SF NS’s are eventuality handy in various drug delivery systems.
Highlights
Silk fibroin (SF) obtained from Bombyx mori silk cocoons are one of the proteins which have been extensively explored in the biomedical and pharmaceutical domain [1, 2]
The current study concludes that the nanoprecipitation method was found to be an encouraging technique for developing the dissolution of poor water soluble drug like TS
The silk fibroin (SF) loaded telmisartan nanospheres were successfully prepared by the nanoprecipitation process in acetone
Summary
Silk fibroin (SF) obtained from Bombyx mori silk cocoons are one of the proteins which have been extensively explored in the biomedical and pharmaceutical domain [1, 2]. G., fibers, nanospheres, films and particles have been reported for various applications [7]. Due to their degradation properties biodegradable polymeric nanospheres have been often proposed to be used in controlled release drug delivery systems [8, 9]. As angiotensin-II is a vasoconstrictor [10], inhibition of its effect on vascular smooth muscles [11] results in decreases in systemic vascular resistance [12]. As a BCS class-II drug, TS is very poorly soluble in H2O, which results in the reduced dissolution and lower bioavailability when dispensed orally [13-15, 3536]. C3H6O functioned both as the solvent of TS and the additive for NS formulation, which assembled the procedure easy and further productive
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