Abstract
Objective: The aim of the present study is to develop solid lipid nanoparticles (SLNs) of Nimodipine using hot homogenization followed by ultrasonication technique and to improve the dissolution characteristics of the drug.
 Methods: The Nimodipine-loaded SLN was prepared using palmitic acid and stearic acid as a lipid matrix and Tween-80 as an emulsifier by a hot homogenization and ultra-sonication method. The physicochemical characteristics of SLN were investigated for entrapment efficiency, zeta potential, in vitro drug release, particle size analysis, Fourier transform infrared studies, scanning electron microscopy, and stability studies.
 Results: The mean particle size, PDI, Zeta potential and entrapment efficiency of optimized Nimodipine SLN formulation of stearic acid was found to be 119.54 nm, 0.165,-17.60mV, 85% and for palmitic acid was found to be 132.54 nm, 0.155,-17.0mV, 81% respectively. In vitro drug release studies indicated that after an initial burst release, SLN could provide prolonged release of Nimodipine. The selected SLNs have shown good stability for a period of 180 d.
 Conclusion: SLN formulations showed the best results in EE as well as in vitro drug release and therefore, these results indicate that SLN might be a promising delivery system to enhance the release of Nimodipine.
Highlights
Solid lipid nanoparticles introduced in 1991 represent an alternative carrier system to tradition colloidal carriers such as emulsions, liposomes and polymeric nanoparticles [1]
solid lipid nanoparticles (SLNs) formulation F4 and A4 composed of Tween 80 as a surfactant and lower concentration of lipid matrix (1000 mg of stearic acid for F4 and 1000 mg of Palmitic acid for A4) showed the best result in view of the entrapment efficiency as well as in vitro drug release; the potential zeta studies showed that the formed particles were in Nano size and possess a negative surface charge
The solubility of Nimodipine was determined by dissolving an excess amount of drug in 200 mg of lipids (Palmitic acid, Stearic acid, Glyceryl monostearate, Glyceryl monooleate, Cetyl palmitate, and cholesterol) in 5 ml stoppered vial and the mixture was mixed by using vortex mixer
Summary
Solid lipid nanoparticles introduced in 1991 represent an alternative carrier system to tradition colloidal carriers such as emulsions, liposomes and polymeric nanoparticles [1]. The system consists of spherical solid lipid particles in nanometre ranges, which are dispersed in water or in aqueous surfactant solutions. They are made of the solid hydrophobic core having a monolayer of phospholipid coating. Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique sizedependent properties, lipid nanoparticles provide the possibility to develop newer therapeutics. Solid lipid nanoparticle is an efficient lipidbased drug delivery system which can improve the bioavailability of poorly water-soluble drugs. NSLN’s were characterized for Scanning and Transmission Electron Microscopy (SEM), Entrapment Efficiency (EE), Stability studies and Zeta Potential
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