Formulation Development and Cevaluation of Mucoadhesive Patch for Diabetes Using Plant Based Polysaccharide

Abstract

Abstract: Using plant-based polysaccharides, this study created a mucoadhesive patch for diabetes with the goal of delivering regulated medication release and improved therapeutic efficacy through sustained contact with the buccal mucosa. The patches' physicochemical characteristics, drug release kinetics, and mucoadhesive strength were examined after they had been made using the solvent casting procedure. . The created patch had exceptional mechanical, flexible, and physical qualities, as well as prolonged drug release and minimized burst release. Through in vitro cytotoxicity tests, the patch's biocompatibility was verified, demonstrating its suitability for buccal administration.the buccal region offcers and attractive route of administration for systemic drug delivery. The patches were prepared by solvent casting method the design of patches were evaluated for thickness, uniformity ,folding ,endurance ,weight uniformity ,swelling behavior,determination of mucoadhesive time. . To confirm the effectiveness and safety of this unique medication delivery method, additional in vivo research and clinical trials are required. If successful, these studies could pave the way for more individualized and efficient diabetic treatment options.