Abstract
Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. To overcome this hurdle, Novel Drug Delivery System (NDDS) proves to be a promising method for formulations containing phytoconstituents. In present work, phyto-phospholipids complex (phytosomes) of Euphorbia neriifolia L. has been prepared to improve the absorption and bioavailability of phytoconstituents. Euphorbia neriifolia L. consists of flavonoids, saponins and polyphenols which possess various medicinal properties. These constituents are hydrophilic in nature and have large molecular size, thus causing poor absorption. Phyto-phospholipids complex of Euphorbia neriifoliahas been prepared by taking Phosphatidylcholine (PC), Cholesterol and Euphorbia neriifolia extract in different ratio and the formulation been optimized to achieve maximum entrapment efficiency and smaller molecular size. The prepared phytosomes has been evaluated by Optical Microscopy, Transmission Electron Microscopy, Dynamic Light Scattering and UV/Vis Spectroscopy for physical appearance, entrapment efficiency, particle size, zeta potential and dissolution rate. The result so obtained indicates the improvement in the absorption rate and bioavailability of the phytoconstituents. Thus, Novel Drug Delivery System (NDDS) possess a great potential in overcoming the challenges of plant based formulations.
 Keywords: Euphorbia neriifolia, Phyto-phospholipids Complex, Novel Drug Delivery System, Phytosomes
Highlights
1.1 Herbal Medicines From last thousands of years, the traditional knowledge of herb drugs has been spread from the old generation to the new generation
From the results obtained it is clear that the Euphorbia neriifolia Linn plant shows the presence of saponins, flavonoids and phenol. 3.4 Quantitative estimation of phytoconstituents 3.4.1 Total phenolic content estimation Principle: The total phenolic content of the extract was determined by the modified FolinCiocalteu method[20]
3.6 Evaluation of Prepared phospholipids Complex The prepared phytosomes has been evaluated by Optical Microscopy, Transmission Electron Microscopy, Dynamic Light Scattering and UV/Vis Spectroscopy for physical appearance, entrapment efficiency, particle size, zeta potential and dissolution rate. 3.6.1 Microscopic observation of prepared phospholipids complex An optical microscope with a camera attachment was used to observe the shape of the optimized phospholipids complex formulation
Summary
1.1 Herbal Medicines From last thousands of years, the traditional knowledge of herb drugs has been spread from the old generation to the new generation. 2. Plant Profile (Euphorbia neriifolia L.) Euphorbia neriifolia Linn (Indian Spurge tree, Hedge Euphorbia commonly known as Snuhi) belong to the family Euphorbiaceae, is one of the different species of Euphorbia genus plants, with wide range of local medicinal uses throughout the areas in which it is grown. Following procedure was adopted for the preparation of extract from the shade dried and powdered herbs15-16: 3.3.1 Defatting of Plant Material 38.5 gram of leaves of Euphorbia neriifolia Linn were shade dried at room temperature. 3.3.2 Extraction by maceration process Defatted Euphorbia neriifolia Linn dried plant material were exhaustively extracted with hydroalcoholic solvent (Ethanol: Water: 70:30). The absorbance was measured at 765 nm using a spectrophotometer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
