FORMULATION DESIGN AND IN-VITRO EVALUATION OF ANTIPSYCHOTIC DRUG QUETIAPINE FUMARATE

Abstract

Although the drug delivery system has been changing with time, the conventional tablet preparation is still domina ting in dosage form preparat ion . Conventional tablet has more advantages than the other formulation s such as low cost of manufacture, package, easier s hipment, tamper proof and stablility for longer duration. Schizophrenia is a severe illness with substantial effects on individual an d social functioning. First - line treatment in these patients is the use of atypical antipsychotics. The atypical antipsychotic Quetiapine was approved in 1997 by the US Fo od and Drug Administration (FDA), and has been available since 2007. The treatment of schizophrenia has changed considerably with the introduction of atypical antipsychotics. Quetiapine is among the most widely used atypical antipsychotics, and along with clozapine has the least prop ensity to induce extra pyramidal motor symptoms. I t is th ought that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine type 2 (D 2 ) and serotonin type 2 (5HT 2 ) receptor antagonisms.The main objective of this work is to develop a pharmaceutical equivalent, stable, robust immediate release tablet. The tablets were prepared by using wet granulation method with sodium starch glycolate and micr o crystalline cellulose used intra and extra granul arly. The dosage form was prepared and evaluated based on various parameter s such as bulk, tapped density, sieve analysis,