Formulation & charecterizaion of anti-microbial property of herbal oral in-situ gel

Abstract

Optimisation, formulation, and characterisation of an oral in situ gel containing clove oil are the focus of the current study. When it came to cross-linking and viscosifying agents, sodium alginate was utilized. The floating agent was sodium bicarbonate. pH were determined to be 7.2 in preformulation experiments. No differences were found between medication and polymers in FTIR spectrums during compatibility testing. There was good pourability in all of the formulas. It took 30 s to float, and it took a total of >12 h to float. Drugs were released from the formulation at a rate of 80–95 percent over 5–6 h during in vitro drug release tests. It was discovered that the concentration of sodium alginate and HPMC had a substantial impact on floating delay, gelling capacity, and cumulative percentage drug release in these experiments. When we tested clove oil (Eugenol) as an antibacterial, we discovered that it demonstrated good zone of inhibition against diverse microbial strains (Staphylococcus aureus and Escherichia coli).