Formulation, Characterization and Release Behaviour of Metformin Hydrochloride Modified Release Tablet by Using Hydrophilic Polymers

T Sivakumar,C N Marimuthu,J Thirumaran,D Kiruthika,S Tamilarasi,S Punitha

doi:10.9734/jpri/2021/v33i59b34395

Abstract

Amongst the many public health problems, the diabetes mellitus is considered as a chronic life-style related disease which is now growing as an epidemic in both developed as well as developing countries. The current study is about formulation of metformin hydrochloride tablet to confirm their sustained release property by using various polymers. The tablets are prepared by granulation techniques using binding solution containing polyvinyl pyrolline K30. The possible interaction between the pure metformin hydrochloride and polymers are identified by Fourier transform-infrared spectroscopy. Tablets were formulated with different polymers like Hydroxy propyl methyl cellulose K100 and sodium carboxymethyl cellulose. Matrix prepared with high concentration of HPMC K100 polymer retards the drug release up to 6 h at 59 %, but the formulation 2 (F2) showed 72.72% of drug release in 6 h. The release of drug from the F2 formulation was found to be prolonged drug release when compared to other formulations. Hence our study conclude that the HPMC K100 polymer containing formulation showed good sustained release property owing to the high gel strength and well high viscosity nature of the polymer.

Highlights

Diabetes mellitus is a chronic disease suffered by approximately 150 million people out of which 35 million people are Indians
Our present study focused to formulate the metformin hydrochloride tablet to confirm their sustained release property by using various polymers such as, Hydroxy propyl methyl cellulose K100 and sodium carboxymethyl cellulose based on their high gel strength and viscosity properties
Metformin hydrochloride sustained release tablet was successfully designed by wet granulation technique

Summary

Introduction

Diabetes mellitus is a chronic disease suffered by approximately 150 million people out of which 35 million people are Indians. The available antidiabetic drugs are used to treat diabetes mellitus and insulin resistance. The antidiabetic drugs are classified as biguanides, thiazolidinediones, the sulfonylureas, benzoic acid derivatives and alpha glucosidase inhibitors. The biguanide drug, metformin is currently prescribed by most of the physicians worldwide. An ideal drug delivery formulation should release required amount of drug inside human body to desired therapeutic effect. Nowadays, sustained release dosage formulations are main focus of the pharmaceutical research field to avoid noncompliance by the patient and to reduce adverse drug reactions. The novel sustained release dosage form should be able to maintain drug concentration in blood and tissue for extended or sustained period of time. The ideal SR dosage form is obtained by trying "zero order" release dosage form without the influence of the delivery system [1,2,3,4]

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Results

Conclusion