Abstract
Acne is the most common skin problem that could occur to any individual. Nigella sativa seed oil and kaolin as natural antimicrobial agents have been utilized in anti-acne cream formulated in this study. This study aimed at the development of anti-acne cream with antimicrobial properties using a crude extract of black cumin (Nigella sativa L.). Anti-acne creams had been formulated from cream-based agents with various percentages of crude black cumin seed extract and 1.0% (w/w) of mineral clay (Kaolin). Physical properties and stability of anti-acne cream at various storage conditions, including incubation at and freeze-thaw at 4, 40, and 45 °C for 28 days. The results showed that developed anti-acne cream containing a crude black cumin seed extract in 0.1 and 1.5% (w/w) had good physical stability. Therefore, the suitable formulation was then tested for anti-Propionibacterium acnes (P. acnes) susceptibility by the broth dilution method. From these results, it was found that 1.0 % (w/w) of crude black cumin seed extract had the ability to inhibit P.acnes with MIC (minimal inhibition concentration) of 15.6 mg/mL.
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