Abstract
Abstract Introduction: Recently, magnetic nanoparticles (MNPs) drew a great attention for application in drug delivery systems. Due to their biocompatibility and non-toxic properties, they have potential to create versatile drug delivery systems. Brimonidine (a relatively selective alpha-2 adrenergic receptor agonist) has a significant effect on lowering intraocular pressure in glaucoma. In this study MNPs were coated with alginate and chitosan and loaded by brimonidine to prepare a drug delivery system applicable in glaucoma treatment. Methods and Results: Brimonidine, sodium alginate and MNPs have been prepared as a dispersion. Chitosan solution was added dropwise to the previous dispersion. The dispersion was centrifuged and the absorbance of the supernatant analyzed by UV spectrophotometer at the λmax of 246 nm. The final dispersion was freeze-dried. The morphological studies of chitosan alginate MNPs(C-A-MNPs) have been done by using transmission electronic microscope (TEM). The release rate of brimonidine tartrate was evaluated by Franz diffusion cell through cellophane membrane. Results showed that more than 93% of the brimonidine tartrate was loaded on the C-A-MNPs. The formulation prepared was stable at room temperature protected from light. Release study showed that less than 40% of the brimonidine was released after 2 hours compared to simple formulation of brimonidine solution which showed more than 80% release after 2 hours. This finding showed sustained release in C-A-MNPs formulation. Kinetic of drug release from C-A-MNPs was slower than blank and followed zero order. The stability of formulation was more than 2 years. Conclusions: It can be concluded that loading of brimonidine on C-S-MNPs may decrease the frequency of administration and increase the efficacy of the product. Key words: Brimonidine, Iron (Ӏ, Π) Oxide, Magnetic Nanoparticles, Ophthalmic Drug Delivery
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