Formulation and Physical Test of Ethanolic Extract Sambiloto Leaves (Andrographis paniculata) Ointment

Indri Kusuma Dewi,Titik Lestari,Siti Nur Rofi'Ah

doi:10.26532/sainsmed.v6i2.603

Abstract

Introduction: Andrographis paniculata had known contained active substance such as andrographolida, atsiri oil, flavonoid, tannin, alkaloid, and saponin which functions as antibacterial, antitoxic, analgesic, and anti-pyretic. Based on its antibacterial properties, an ointment form of Andrographis paniculata leaf is then formulated, for practical usage. Ointment formula is semi solid for topical use in the skin or mucosal membranes. Objectives: to know the result of ointment physical test of etanolic extract Andrographis paniculata leaf. Methods: physical tests contain organoleptic test, pH, homogenity, adhesion test and dispersive test. Results: Ointment shaped semi solid, blacky green and special smell of Andrographis paniculata, pH 6, homogenity test obtained homogenous results, adhesion test was 82 second and dispersive test was 5.6 cm. Conclusion: the result of physical tests of etanolic Andrographis paniculata leaf extract ointment appropriate with quality standard.

Highlights

Andrographis paniculata had known contained active substance such as andrographolida, atsiri oil, flavonoid, tannin, alkaloid, and saponin which functions as antibacterial, antitoxic, analgesic, and anti-pyretic
Ointment formula is semi solid for topical use in the skin or mucosal membranes
This research is a descriptive study to illustrate the results of Sambiloto leaves extract’s ointment physical tests, presented in the form of numbers, narration, text and frequency distribution table

Summary

Introduction

Andrographis paniculata had known contained active substance such as andrographolida, atsiri oil, flavonoid, tannin, alkaloid, and saponin which functions as antibacterial, antitoxic, analgesic, and anti-pyretic. Objectives: to know the result of ointment physical test of etanolic extract Andrographis paniculata leaf. Results: Ointment shaped semi solid, blacky green and special smell of Andrographis paniculata, pH 6, homogenity test obtained homogenous results, adhesion test was 82 second and dispersive test was 5.6 cm. Conclusion: the result of physical tests of etanolic Andrographis paniculata leaf extract ointment appropriate with quality standard. Plants are natural resources which contains many natural benefits as medicinal ingredients. One plant used as ingredient for traditional medicine in Indonesia is Sambiloto (Andrographis paniculata). Sambiloto is known contain active substances such as andrographolida, essential oils, flavonoids, tannins, alkaloids and saponins. Part of the sambiloto that may provide a therapeutic effect is the leaves (Lukistyowati, 2012)

Objectives

Methods

Results

Conclusion