Formulation and physical properties observations of soy lecithin liposome containing 4-n-butylresorcinol

Abstract

Liposomes are preparations which have many advantages such as high solubility and good stability. The 4-n-butylresorcinol has the effect of hypopigmentation and, similar to resorcinol, is unstable. Liposomes could, therefore, assist the development of 4-n-butylresorcinol in a more appropriate dosage form. The research presented in this article aimed to determine the effect of the concentration of soy lecithin phospholipids to the liposome particle size. Subsequently, the effect of adding 4-n-butylresorcinol as the active compound to the liposomes in the particle size and morphology of the liposomes is also presented. The preparation of liposomes was assisted by sonication, and subsequently, the active compound 4-n-butylrecorcinol was added. Particle size and morphology of liposomes were then characterized as the observed parameters. In this research, there was no evidence that the size of the liposomes was significantly affected by the concentration of phospholipids. Notably, the particle size and morphology of liposomes with 4-n-butylresorcinol as the active substance were not significantly different compared to the liposomes without 4-n-butylresorcinol.