Abstract
Infected bone abnormalities are a difficult clinical problem to cure. In this study, a chitosan/sodium alginate temperature-sensitive hydrogel scaffold (CHX@BMP-2-TH) was developed and described with chlorhexidine/β-cyclodextrin (CHX/β-CD) and chitosan/bone morphogenetic protein (CS/BMP-2). The results revealed that adding CHX/β-CD and CS/BMP-2 to the hydrogel improved the mechanical properties and reduced the internal porosity; CHX@BMP-2-TH stimulated MC3T3-E1 osteogenesis and inhibited E. coli and S. aureus growth. CHX@BMP-2-TH is a unique bioactive substance that could be used to treat infectious bone abnormalities.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
