Abstract
Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Lamivudine using Sodium Chloride as Osmogen for the Treatment of AIDS
Highlights
The discovery of HIV as the causative agent of acquired immune deficiency syndrome (AIDS) by Sinoussi et al in 1983 [1], HIV/ AIDS is a major threat to population health in the world
Short term stability study on the best formulation indicated that there was no significant changes in thickness, friability, weight variation, drug content and in vitro drug release
WHO estimate in 2015 showed that 36.7 million people globally [2] were living with HIV, AIDS killed 1.1 million people died from AIDS related illnesses and 35 million people have died from AIDS related illness since start from epidemic
Summary
The discovery of HIV as the causative agent of AIDS by Sinoussi et al in 1983 [1], HIV/ AIDS is a major threat to population health in the world. The present study is to develop controlled porosity osmotic pump tablets of lamivudine. Once CPOP tablets come in contact with the aqueous environment [5] of biological system the water soluble component dissolves and an osmotic pumping system is created in the core. Water diffuses into the core through the micro porous membrane setting up an osmotic gradient and thereby controlling the release of drug. The rate of drug delivery depends upon the factors such as water permeability of the semi permeable membrane, osmotic pressure of core formulation, thickness and total area of coating. Lamivudine is a synthetic nucleoside analogue and is phosphorylated intra cellularly to its active 5’-triphosphate metabolite, lamivudine triphosphate (L-TP) This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase resulting in DNA chain termination [6]. The main objective of the present study was to develop controlled porosity-based osmotically controlled release tablets of lamivudine
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