Abstract
Background: Oral disintegrating tablets are engineered to dissolve in saliva extremely quickly, typically within a matter of seconds. Aim: The aim of the research was to develop and assess aceclofenac Oral Disintegrating Tablets (ODT) through wet granulation, employing natural super disintegrants in different concentrations. Methods: The chitosan was isolated from the prawn shell using different concentrations of formulated trails, including F1, F2, F3, F4, and F5. Aceclofenac orally disintegrating tablets were prepared and characterized for various parameters including hardness, friability, weight uniformity, drug content, disintegration time, and in vitro dissolution studies. Results: Among the formulations, F5 exhibited superior performance in terms of rapid disintegration with 29 sec and the highest percentage of drug release with 98.91% compared to the others. Conclusion: Increasing the concentration of isolated chitosan from prawn shell results in an increased dissolution profile and a decrease in disintegration time.
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