Abstract
Aim: This work focused on the development of transferrin-conjugatedtheranostic liposomes consisting of docetaxel (DXL) and upconversion nanoparticlesfor the diagnosis and treatment of gliomas. Materials & methods:Upconversion nanoparticles and docetaxel-loaded theranostic liposomes were prepared by a solvent injection method. Formulations were analyzed for physicochemical properties, encapsulation efficiency, drug release, elemental analysis, cytotoxicity and fluorescence. Results: The particle size was around 200nm with spherical morphology and an encapsulation efficiency of up to 75.93%, was achieved for liposomes with an invitro drug release of 71.10%. The IC50 values demonstrated enhanced cytotoxicity on C6 glioma cells with targeted liposomes in comparison with nontargeted liposomes. Conclusion: Prepared theranostic liposomes may be promising for clinical validation after an invitro and invivo evaluation on cell lines and animals, respectively.
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