Abstract
Febuxostat Immediate Release Tablet were prepared by direct compression method using varying concentrations of Lycoat, Crospovidone & Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for Precompression& post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat + excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.45% of the drug release within 40 min & follows first order kinetics.
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