Formulation and In-Vitro Evaluation of Amoxicillin Mucoadhesive Microcapsules for the Treatment of Helicobacter pylori Infection

Abstract

Event Abstract Back to Event Formulation and In-Vitro Evaluation of Amoxicillin Mucoadhesive Microcapsules for the Treatment of Helicobacter pylori Infection Senthil Adimoolam1*, Bolai Paul1 and Mohd Javed Quereshi1 1 Mahsa University, Malaysia Background Amoxicillin (α-amino-p-hydroxybenzyl-penicillin) is a semi-synthetic, orally absorbed and widely prescribed β-lactam antibiotic. It is widely used for eradication of gastric Helicobacter pylori infection combined with a second antibiotic and an acid‐suppressing agent despite its short elimination half-life of one hour. The purpose of this study was to develop and evaluate amoxicillin loaded HPMC K15M mucoadhesive microcapsules for sustained drug release at the gastric mucosa to prolong residence time of dosage form in stomach to achieve more effective H. pylori eradication. Methods Amoxicillin mucoadhesive microcapsules were formulated by ion gelation technique by using different mucoadhesive polymers HPMC K15M and sodium alginate with varying concentration. A 32 full factorial design was applied to derive statistical equation, ANOVA analysis, contour plots and 3D response surface plots. The nine formulations were subjected to evaluation of percentage yield, entrapment efficiency, swelling index, mucoadhesion and in vitro drug release. Results Among nine formulations (F1 – F9), F9 exhibited a promising drug entrapment efficiency (92.50±0.03%), percentage yield (97.50±0.02%), percentage mucoadhesion (65±0.03 after 8 h) and in vitro drug release more than 14 h. The kinetics of the drug release of microcapsules (F9) showed good fitting with zero order and Korsmeyer-Peppas model followed by a non-Fickian release. The ANOVA analysis shows highly significant effects on depended variable. Conclusion Therefore, amoxicillin mucoadhesive microcapsules can be effectively used in the treatment of H. pyloriinfection. Acknowledgements Authour would like to thank MAHSA University Management for financial support fro this research Keywords: microcapsule, Amoxicillin, mucoadhesion, Entrapment efficiency, Percentage yield Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Adimoolam S, Paul B and Quereshi M (2019). Formulation and In-Vitro Evaluation of Amoxicillin Mucoadhesive Microcapsules for the Treatment of Helicobacter pylori Infection. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00075 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Senthil Adimoolam, Mahsa University, Kuala Lumpur, Malaysia, senthil@mahsa.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Senthil Adimoolam Bolai Paul Mohd Javed Quereshi Google Senthil Adimoolam Bolai Paul Mohd Javed Quereshi Google Scholar Senthil Adimoolam Bolai Paul Mohd Javed Quereshi PubMed Senthil Adimoolam Bolai Paul Mohd Javed Quereshi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.