Formulation and In-vivo Assessment of Topical Polyherbal Hair Serum to Promote Hair Growth

Abstract

Male pattern baldness, or androgenic alopecia, is a term used to describe hair loss that results from the underlying sensitivity of hair follicles to androgenic shrinkage. Alopecia is caused by environmental factors, hormone imbalances, and/or inherited factors, according to research studies, however, many etiologies are still unclear. The purpose of treating androgenic alopecia is to slow down the thinning of hair and promote hair growth. A small number of natural treatments, along from allopathic medicines, have demonstrated effectiveness in the decades-long combat over alopecia. The main object of the present study was to develop and in-vivo evaluation of hair growth serum. Crude herbs extract of Hibiscus rosa-sinesis, Glycyrrhizza glabra, Eclipta alba, Withania somnifera and Bacopa monnieria were specifically weighed to make polyherbal serum and animal models are rats with induced androgen test to access for hair growth promoting activity. To assess the serum’s potential against alopecia, it was applied topically. Testosterone had been administered subcutaneously for 20 days to cause alopecia in albino rats. Serums made of herbal extracts were administered concurrently to prevent androgen from having the ability to cause baldness. A positive control was provided with finasteride. At the conclusion hair growth activity was assessed visually, follicular density was measured using an ocular micrometer, and the anagen/telogen ratio was measured using an animal skin sample.