Abstract
The objectives of present investigation were to prepare and evaluate liquid crystalline gel, study the effect of water concentration on liquid crystalline phases, incorporate antifungal agent and itraconazole (ITZ) co-crystals into liquid crystalline vehicle. Liquid crystalline gel formulations were prepared by using glyceryl mono-oleate GMO, water and other excipients. The prepared gel formulations were evaluated for various parameters like rheological, in vitro drug diffusion and in vivo skin irritation test etc. Differential scanning calorimetric spectra of ITZ loaded gel showed higher transition peak temperature 96.71oC and ITZ loaded co-crystal gel showed 99.2oC and pH 6.8 and 6.5 respectively. Enhanced rate of diffusion was observed when gels were loaded with co-crystals. The prepared liquid crystalline gel formulations containing itraconazole and its co-crystals were found useful in a topical delivery with improvement for in vitro and in vivo performance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
