Formulation and In Vitro Evaluation of Tropisetron Loaded Microspheres

Abstract

Tropisetron is a 5-HT3(5-hydroxytryptamine3) receptor antagonist used fortheprevention of chemotherapy-induced nausea and vomiting. In the present study, ethyl-cellulose, sodium alginate and HPMC K15M loaded microspheres of tropisetron were successfully prepared by ionic gelation technique. All the formulations were evaluated forvarious parameters such as drug content, entrapment efficiency, in vitrodissolution study, release kinetic study and stability study. The in vitro dissolution studies showed that tropisetron microspheres formulation F10 havebetter sustained effect over a period of 12 hours which contains all three polymers having a perfect controlled release. The mechanism of release was determined byvarious kinetic equations such as zero-order, first-order, Higuchi, Hixon Crowell, Korsmeyer-Peppas and finding the R2values of the release profile corresponding to each model. Thus, in thepresent study,in vitro drug release kinetic of the best formulation followed zero order release kinetic model and the drug release mechanism was anomalous diffusion. The results of the current study clearly indicate a promising potentialdelivery systemof the tropisetron microsphere as an alternative to the conventional dosage form