Abstract
Natural gums are economical, easily available, and useful as tablet binders. In the present investigation, an attempt was made to formulate Ofloxacin tablets using three natural binders, namely Acacia arabica, Hibiscus esculentus, and xanthan gum. Such six batches of Ofloxacin tablets were prepared by using different types and amounts of the natural binders by the wet granulation method. The tablets were analyzed for their hardness, friability, and weight variation, and in vitro release was performed in a phosphate buffer at pH 6.8. The prepared tablets were also evaluated for their various release kinetics and similarity factors f2. The physical properties of the tablets containing the natural binders showed sufficient hardness, desirable disintegration time, and low friability. Their better percentage of drug release was observed as compared to the marketed formulation showing more than 85% drug release within 45 minutes. The in vitro release data was well-fitted into zero-order and the values of release exponent ‘n’ were between 0.303 and 0.514. The high similarity factor f2 of 64.50 was achieved with the best batch in comparison to the marketed tablets. The results obtained indicated that the gum Acacia arabica performed as well as gelatin compared to the other binders for the Ofloxacin tablet formulation.
Highlights
Due to their portability and convenience, tablets are the most widely prescribed dosage forms in the world
The results obtained indicated that the gum Acacia arabica performed as well as gelatin compared to the other binders for the Ofloxacin tablet formulation
The tablet hardness was between 40–50 Newton, the friability less than 1%, and the disintegration time less than 30 minutes, which was within pharmacopoeial limits [17]
Summary
Due to their portability and convenience, tablets are the most widely prescribed dosage forms in the world. Binders are pharmaceutical excipients that are commonly employed in tablet formulations to impart cohesion on the powder mixture and improve the flow properties on the granules. Natural binders like different starches, gums, mucilages, and dried fruits possess binding capacity as well as some other properties like being a disintegrant, filler, and having sustained release. These natural polymers are much safer and more economical than polymers like polyvinylpyrrolidone (PVP) [3, 4]. (Family: Malvaceae), commonly known as bhindi in India, krajiab kheaw in Thailand, okra plant, kopi arab, kacang bendi, and bhindi in Southeast Asia, is a tropical to subtropical plant that is widely distributed across Africa to Asia, Southern Europe, and America. Xanthan gum consists of glucose, mannose, and glucuronic acid, and is used in different foods as a thickener and stabilizer [7]
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