Formulation and in-vitro evaluation of Niosomes of Aceclofenac

Abstract

The present research work was to formulate and evaluate the site specific delivery of aceclofenac niosomes in order to overcome the problem of GI discomfort and to produce a better therapeutic response. Niosomes of Aceclofenac were formulated by an Ether injection method using different concentrations of drug, cholesterol and surfactant (Span 60). The formulations were evaluated from the various methods like vesicle shape, particle size, entrapment efficiency, drug content, compatibility studies and in-vitro drug release. Ether injection method was found to be most satisfactory with respective to niosomes particle size, drug entrapment efficiency, in-vitro drug release and its release mechanism was followed by krosmeyer Peppas method R2 =0.9840.