Abstract
Eye is the most unique organ of the body. Various drug delivery systems are used to deliver drug into the eyes but there are various limitations of conventional systems, so various novel approaches like nanovesicular systems were used to improve ocular contact time, bioavailability, residence time and dosing frequency.Nanovesicular system with elastic properties can provide a controlled delivery of Methazolamide (MZA) which is used to treat glaucoma by inhibiting the action of carbonic anhydrase enzyme. The elastic nanovesicular carriers were formulated using Span 60 (SP 60) with one of the following edge activators (EA): Tween 80 (TW80), Tween 60 (TW 60), Brij 35 (BJ 35), and Brij 58 (BJ 58) in the ratio (90:10; 80:20; 70:30 w: w). The prepared formulae were evaluated for their sizes, entrapment efficiencies (EE %), relative deformability, and in vitro release. The results show that the selected formulae (S1, S4, S7, and S8) have the suitable particle size and EE%, thus can be used for any further investigations.
Highlights
Eye contains several protection mechanisms which decrease ocular drug absorption topically and lead to short duration of action
Different ratios of Span 60 to edge activators were tested in order to choose the formulae which show the highest encapsulation efficiency along with small size to be used for further investigations
Data shown in Table (1) reveals that the percentage of MZA entrapped in the prepared elastic vesicular systems were in the range of 23 to 94%
Summary
Eye contains several protection mechanisms which decrease ocular drug absorption topically and lead to short duration of action. Methazolamide (MZA) is a weakly acidic sulfonamide derivative which is slightly soluble in water. It is indicated for the treatment of glaucoma by inhibiting the action of carbonic anhydrase enzyme. Elastic vesicular systems that consist of a mixture of span together with different edge activators, can be used to increase the drug residence time and its ocular bioavailability (Kakkar and Kaur, 2011). Materials Methazolamide (MZA) was purchased from Jiaxing Taixing chemical and Pharma Co, ltd (Jiaxing, China). Centrifuge (Herml, Z 216MK centrifug, Gosheim,Germany), particle size analyzer NanoZS (Malvern instruments, Malvern, UK), Rotary evaporator (Janke and Kunkel, IKA Laboratories, Germany), USP dissolution apparatus (Pharma test, Hainburg, Germany), and UV- Visible spectrophotometer (model UV -1601pc; shimadzu,Kyoto, Japan)
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