Formulation and In vitro Evaluation of Gastroretentive Floating Tablets of Macrolide Antibiotic Based on Effervescent Technology Using Clarithromycin as a model drug

Abstract

The present study was carried out with an objective of preparation and in vitro evaluation of floating tablets of Clarithromycin by using HPMC K4M and HPMC E15LV. The floating tablets were based on effervescent approach using sodium bicarbonate a gas generating agent. The formulated tablets were investigated for the quality control tests such as weight variation, hardness, friability, swelling index, floating lag time, and total floating time. The in vitro release study of the tablets was performed in 0.1N HCl as a dissolution media. The results of the present study clearly indicates the promising potential of Clarithromycin floating system as an alternative to the conventional dosage and other sustained release formulations. The drug release of optimized formulation was found to follow zero order and Korsmeyer‐Peppas kinetic models and r2 value nearer to one and n value was found to be 0.8420 and 1.0703. Formulation F13 exhibited better Gastroretentive controlled drug release in comparison to other prepared formulation.