Abstract
Formulation and In Vitro Evaluation of Ciprofloxacin Matrix Tablets: Effect of Drug-Polymer Ratio
Highlights
Drug delivery systems are engineered technologies, formulations, approaches and systems for delivering a pharmaceutically active compound to elicit the desired therapeutic effect
A number of polymers such as hydroxypropylmethylcellulose (HPMC), xanthan gum, cashew gum and guar gum have been used in drug delivery.[2,3,4,5]
In tablets containing xanthan gum and HPMC, there was an increase in crushing strength as the amount of polymer was increased to equal amount with the drug 1:1
Summary
Drug delivery systems are engineered technologies, formulations, approaches and systems for delivering a pharmaceutically active compound to elicit the desired therapeutic effect. A number of polymers such as hydroxypropylmethylcellulose (HPMC), xanthan gum, cashew gum and guar gum have been used in drug delivery.[2,3,4,5] there is growing need to device new methods of improving the efficacy of drugs and control their pharmacokinetics. Ciprofloxacin is a second-generation fluoroquinolone with a wide range of activity against gram-positive and gram-negative bacteria.[9] It is indicated in the treatment of bone infection, typhoid fever and throat infections It inhibits DNA gyrase in susceptible organisms and promotes breakage of double-stranded DNA.
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