Formulation and in-vitro Evaluation of Baclofen loaded Transferosomal Gel

Abstract

Baclofen is a class of medications called skeletal muscle relaxant. It is a class III drug having low solubility and high permeability used in treating multiple sclerosis symptoms such as spasticity, stiffness, and pain. The current study involves the development and in-vitro evaluation of a Baclofen-loaded transfersomal gel to reduce dosage frequency. Drug and excipient interactions were not detected in the FTIR spectra. Hand shaking modified thin film hydration method was used to developed transfersome formulations, which then consolidated at 0.5% carbopol gel. Optimized BF7 formulation provides higher Entapment efficiency and maximum drug delivery. The prepared formulation had been examined for FTIR, Organoleptic evaluation, Viscosity, Spread-ability, Entrapment Efficacy, Drug content, SEM analysis, Particle size, Zeta potential, Stability testing, and other parameters. The optimised formulation BF7 confirmed Entapment Efficiency ranging from 80.04 to 87.42%, Drug content ranging from 90.26 -95.37%, Vesicle Size of 167.8nm & In-vitro diffusion of 97.48%. The drug release data from the chosen gel demonstrated a good fit with the Higuchis and Zero order release kinetics.
 Keywords: Transferosomes, vesicular drug delivery system, Thin film hydration method