Formulation and evaluation sustained and immediate release bilayer tablet of telmisartan and amlodipine

Abstract

The study was undertaken with the aim to Formulation and evaluation of bilayer tablet formulation of Telmisartan and Amlodipine. Thus, from the results, it is concluded that the formulation of immediate release layer of Amlodipine using 4-2% concentration of Crospovidone & PVA K30 and 30-20-1.5% concentration of HPMC K 100M-HPMC K4 M-HPMC K15 M are considered as ideal for optimized bilayer tablet formulation. The drug release data of the Telmisartan and Amlodipine was fitted into various kinetic models which as shown in figures 3.8 and 3.11. The order of release of drug was found to be zero order, in which R2 value was close to 1. The n value of Korsmeyer Peppas equation was found to be 0.746. Good correlation coefficients are obtained for Higuchi equation. The results showed that the formulation followed Peppas Model release. Thus, this optimized bilayer tablet formulation can be successfully used in the treatment of hypertension. This modified release bilayer tablets also reduced dosing frequency, increase the bioavailability and provide better patient compliance. From the results it was found that formulation F4 was the best formulation amongst the 5 formulations.