Abstract
Objective: The aim of this research is to formulate and evaluate the wound healing gel of Leucaena leucocephala leaves extract. Methods: In this research, the extract of Leucaena leaves was formulated into wound healing gel by using a variation of the concentration of Carbopol as a gelling agent and Propylene glycol as a humectant. Afterward, the gel's physical properties (pH, viscosity, spreadability), stability, and sterility were tested. The wound healing activity was evaluated by making excision wounds on the Wistar Albino rat's back, and then the gels were applied to the wound every day. The wound's size was measured and counted as the percentage of wound closure. Results: The result showed that Formula 4 (contains 1.5% of Carbopol and 12% of Propylene glycol) has the best physical characteristics and wound healing activity. Formula 4 showed 100% wound closure on the 11th day of the treatment, while the negative control only reached 49.12%. The statistical parameter with the p-value<0.05 stated that they are significantly different. Conclusion: This research demonstrated that gel with Leucaena leaf extract has good physical characteristics, and it can significantly improve the wound healing process.
Highlights
Wound, an incident often experienced by humans in daily activities, is defined as the broken of skin tissue [1]
The election is taken with the consideration of the solubility of the active constituents having wound healing activity existed in Leucaena leaf [21]
Propylene glycol is a humectant that has a vital role in topical preparations by maintaining skin moisture and increasing water absorption from the epidermis to the deeper parts of the skin [25]
Summary
An incident often experienced by humans in daily activities, is defined as the broken of skin tissue [1]. The wound healing process consists of several stages started from inflammation, a proliferation that includes epithelialization, angiogenesis, and skin remodeling [3]. During those complex processes, it is necessary to maintain the wound's sterility, protect the wound from contamination that can cause infection, prevent dehydration (moisture is needed for the new tissue arrangement), and absorb or eliminate the wound exudate [4]. The high water content in the gel formula is suitable for the environment needed for wound healing It creates a moist environment and absorbs wound exudates to accelerate the wound healing process [5]. It is applied and removed from the skin [7]
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