Abstract
Wounds result in functional disruption of living tissues. Herbs and their extracts have potential to regenerate damage skin. Purpose of this study was to evaluate the wound healing activity of aloe vera leaf extract in combination with curcuma longa extract. Both herbs possess anti-inflammatory and antibacterial properties. Gel-I and Gel-II were formulated using Carbopol 940, 3%w/w aloe vera leaf extract, 1 and 3%w/w curcuma longa extracts respectively and were applied on excision and incision wounds created on albino rabbits. Animals were divided into four groups having six animals, group-I was control, group-II received standard gel (Nitrofurazone), group-III received Gel-I, group-IV received Gel-II. Gels were evaluated for color, pH, clarity, viscosity, consistency, spreadability, extrudability, skin irritation test and stability studies. Gels were applied on excision wound once a day for 12 days. Wound treated with Gel-II showed better healing activity and greater percentage of wound contraction (p<0.05) than 1%w/w. Histology was carried out on skin of 5th and 12th day incision wounds. Gel-II showed better epithelialization time, wound contraction, tensile strength. Wound healing activity was because of antibacterial, anti-inflammatory and antioxidant properties of phytoconstituents of aloe vera and curcuma longa.
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