Abstract
Tropicamide is an antimuscarinic drug used in eye disease. The niosomal vesicular drug delivery system facilitate the permeation of drug through the cornea because of the micron/nano size of vesicles containing drugs, which will increase the corneal penetration of drug, and increase the residence time of formulation in ocular cavity that result to increase the bioavailability of drug. Tropicamide loaded Niosomes by investigating the relationship between drug/Nonionic surfactant ratio were successfully prepared by thin film hydration method and compare the result of different grade of span used (20,40,60) with different ratio of cholesterol. niosomes were evaluated for particle size ,drug entrapment efficiency, drug content ,corneal permeation study and in–vitro drug release. Respectively as a result the niosomes designed showed nearly spherical particles with a mean particle size 156.3nm. Niosomes prepared using cholesterol and span 60 in the ratio (1:1) f9 shoed higher entrapment efficiency (84.35%) in-vitro drug release (94.02%) was optimized. Keywords: Niosomes, in-situ gel, vesicles, ocular cul-de-sac, viscoelastic gel.
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