FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF HYDROXYCHLOROQUINE SULPHATE

Abstract

The aim of the present study was to investigate the patch for transdermal Hydroxychloroquine delivery in an effort to mask the bitter taste when orally administered. Hydroxychloroquine has easily measurable outputs that are linked to increased renal Na+ excretion. We thus monitored urinary Na+ output in separate groups intravenously administered Hydroxychloroquine or topically applied patch. Transdermal therapeutic systems are high- tech patches that make treatment much more convenient and pleasant for patient .Instead of having to take lots of tablets, patients often only have to apply a new patch once a week In addition, patches from LTS also ensure a constant drug level for the entire duration of wear Symptoms upon getting up in the morning as a result of low drug levels during the night are avoided. There are five major advantages of transdermal patches above other systems like Improved well –being for patient, constant drug levels, fewer side effects, Drugs that cannot be absorbed via the gastrointestinal tract can now be used and because the substance is released evenly and directly into the blood stream, less of the substance may be required.