Abstract
<p>The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the<italic> in vitro</italic> release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (<italic>p</italic>> 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.</p>
Highlights
Transdermal-patch technology has advanced tremendously since the first scopolamine patch was introduced into the market in 1979
It can be attributed to today’s advanced patch-making technology, through which nearly a billion patches are manufactured every year (Prausnitz, Langer, 2008). These transdermal patches are classified into three types: drug in adhesive, reservoir and matrix (Tan, Pfister, 1999; Subedi et al, 2010)
Loss of consciousness appears in patients when angina pectoris breaks out, and it is difficult for patients to take the medicine by themselves
Summary
Transdermal-patch technology has advanced tremendously since the first scopolamine patch was introduced into the market in 1979. It can be attributed to today’s advanced patch-making technology, through which nearly a billion patches are manufactured every year (Prausnitz, Langer, 2008). These transdermal patches are classified into three types: drug in adhesive (the drug is directly dispersed into the adhesive polymer), reservoir (consists of a drug reservoir between a backing membrane and rate-controlling membrane, with a skin-contacting adhesive layer) and matrix (consists of a drug reservoir in the centre with a peripheral adhesive ring around the edges) (Tan, Pfister, 1999; Subedi et al, 2010). Isosorbide dinitrate (ISDN) is commonly used for the therapy of stable angina pectoris and is traditionally administrated via oral or sublingual routes. Transdermal delivery may be an appropriate administration route for ISDN
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