Abstract
The research work was aimed at developing and optimizing erythromycin estolate throat paint solution for improved bioavailability in the oral delivery of based throat paint is prepared by unique method. Potassium iodide, glycerol has been selected based on mouth paint, mucoadhesive strength, and the drug the medication with the goal of treating wooping cough. Erythromycin estolateis released in vitro. A 32factorial prototype was used to preparation the throat paint at concentration of potassium iodide and glycerol was used as an independent variable released in vitro and permeated by percentage.For throat paint, the percentage of mucoadhesion, product consistency,releaseof drugs in vitro, and percentage of rest from permeation were calculated. With mucoadhesive strength, percentage permeation and in-vitro drug releaseperformance, formula f9 has been optimized. Studies of FTIR and have characterised throat paint. Study of stability revealed stable formulation was found.
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