FORMULATION AND EVALUATION OF THERMO-RESPONSIVE OCULAR IN SITU GEL OF CIPROFLOXACIN AND OLOPATADINE HCL

Abstract

Ocular in situ gel (ISG) is a promising alternative to alleviate the shortcomings of conventional formulations due to their association with dose accuracy and effective administration with prolonged contact time. Therefore, present research aimed to develop a thermo-responsive in situ gel (TRISG) for ocular drug delivery (ODD) with different levels of Pluronic® F407 and Pluronic® F188 for ciprofloxacin HCl (CFH) and olopatadine HCl (OLH). The three optimal formulations were selected based on the physicochemical characterization of nine batches and were evaluated successfully. The batch F5 of CFHOLH-TRISG explored the remarkable outcomes within acceptable limits in aspects of physicochemical characterization and other parameters. The TRISG has proven to release over 120 min, which was more significant than conventional drops (60 min), suggesting sustained release and better corneal penetration. A compressive finding explored the TRISG with combination might be a pragmatic choice for ODD with effective administration, enhanced ocular bioavailability, and sustained release.