Abstract
Background: Cucumber extract is often used for skin problems, wrinkles, sunburn, and as an antioxidant. Thereby, the main objective of the present investigation was to develop a topical skincare cream (w/o) loaded with the sea cucumber, Holothuria arenicola extract (HaE). Methods: Oil in water emulsion-based cream was prepared by incorporating liquid paraffin, soft wax, cetostearyl alcohol in the oil phase, and borax in the water phase respectively with 1 gm of HaE. The evaluation of HaE cream was done on different parameters like ph, viscosity, spreadability, extrudability, irritancy and stability. Results: HaE showed good appearance, homogeneity, spreadability, diffusion, consistency, pH, extrudability, and spreadability without any irritancy to skin. The present results showed that HaE cream has radical scavenging activity in range from 57 to 70 % and NO scavenging activity in range from 25 to 49 %. Conclusion: The formulated HaE cream was successfully developed that met the relevant pharmaceutical characteristics form. The developed HaE cream could be added in topical formulations in order to protect skin against damage caused by free radicals due to its antioxidant activity.
Highlights
Cosmeceuticals are cosmetic-pharmaceutical hybrids, containing active ingredients in creams, lotions, and ointments [1]
The present results showed that Holothuria arenicola extract (HaE) cream has in vitro antioxidant activity as indicated by dose dependent inhibition of DPPH radicals in range from 57 to 70 %
The application of active antioxidant substances in cosmetic formulations stems from their ability to protect the skin against oxidative damage by UV radiation and aging
Summary
Cosmeceuticals are cosmetic-pharmaceutical hybrids, containing active ingredients in creams, lotions, and ointments [1]. Creams are semisolid dosage forms that contain one or more drug substances deliberated for application to the skin or mucous membrane. Oil in Water (O/W) emulsions are the most commonly used cosmetic delivery systems that supply moisture to the skin and improve the skin condition by forming the occlusive barrier on the skin. [2,3]Natural formulations of cosmetics have a growing demand in the world market and are an invaluable gift of nature. These formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Thereby, the main objective of the present investigation was to develop a topical skincare cream (w/o) loaded with the sea cucumber, Holothuria arenicola extract (HaE)
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