Formulation and evaluation of tamarind seed polysaccharide matrix tablet

Abstract

Objective: The objective of using natural polymer was to modify the release rate of Diclofenac sodium from matrix tablet. The matrix forming agent like Tamarind seed Polysaccharide show sustained release property in tablet which is obtained naturally from fruit of Tamarindus indica L. belonging to Family Leguminosae. Methods: The sustained release matrix tablet of Diclofenac sodium were prepared by wet granulation technique using varying concentration of hydrophilic polymer i.e. TSP. Results: OF1 and OF2 both are optimized batch. The in vitro dissolution study was carried out for optimized as well as marketed formulation (Voveran- SR). Both the optimized batchesat 10 h were found to be 90.27% and 90.18%, respectively. Conclusions: Tamarind seed polysaccharide can be employed in dosage form to sustain the drug release. Tablet formulated with various concentrations of Tamarind seed polysaccharide (TSP) gives release up to 10 h and more. OF1 and OF2 both formulations give comparable release with marketed formulation. From the present work it can be conclude that, the objectives which were set at the beginning of the study got fulfilled.