Abstract
The objective of this research was to formulate fast dissolving sublingual film of Hydralazine hydrochloride for rapid action. Hydralazine hydrochloride is a direct acting smooth muscle relaxant used to treat hypertension. It belongs to the hydrazinophthalazine class of drugs. Solvent casting method was adapted to prepare the sublingual films by using a 32 full factorial design. of their components or with individual components 1. FT-IR and Dissolution studies revealed that there was no physico-chemical interaction between Hydralazine hydrochloride and other polymer. All formulations are evaluated for tensile strength, weight variations, moisture content, mucoadhesion strength, in-vitro disintegration study, in-vitro dissolution study, uniformity of drug content, surface pH, % elongation break ,folding endurance. F6 batch contain Hydralazine hydrochloride (Drug), PVA, PVPK-30 and PEG-400. F9 batch was the optimized batch since it showed of Disintegration time (59 sec), surface PH (6.80) and %Drug release (98.55%).
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