Abstract
Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The study included formulation of floating tablets using polymers like Hydroxypropylmethylcellulose K4M and Carbopol 934 as matrix forming agents. The tablets were directly compressed using multi station rotary punching machine. FTIR studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the Pharmacopoeias limit. Tablet showed buoyancy for >12 h. The in- vitro drug release pattern of floating tablets was fitted to different kinetic models which showed highest regression for higuchi model. Formulation E6 found stable during 1 month stability study.
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