Abstract
Background Superficial fungal infections can lead to many complications and serious issues. A diverse range of topical agents such as Ciclopirox olamine CPO are available for the treatment of dermatophytes bacteria yeasts and filamentous fungi. CPO is a highly lipophilic drug with very limited systemic absorption. Hence a specific dosage form of CPO was designed to increase its half-life for providing prolonged drug delivery as well as minimizing the side effects.Objective To develop a CPO-containing topical niosomal gel formula and to examine its stability and compatibility with others.Methodology The prepared niosomal gel was kept in sealed glass containers and preserved under refrigerated and room temperature conditions for 6 months. At the end of the 4th and 8th weeks and 3rd and 6th months the samples were collected and tested for various parameters.Results There were no significant changes in the physicochemical properties such as pH viscosity drug content and release profile.Conclusion Niosomal gel is stable when refrigerated as well as at room temperature.Keywords Ciclopirox Stability study Niosomal gel Fungal infectionnbsp
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