Abstract
Solid dispersions are an effective method of increasing the solubility and bioavailability of poorly soluble drugs. In the present study it is aimed at to enhance solubility of Nabumetone a poorly soluble anti-inflammatory drug by solid dispersion technique by employing solvent evaporation technique using PEG 4000 And PEG 6000 as carriers. The formulations were prepared in ratios of 1:1, 1:2 , 1:3, 1:4 and characterized by FTIR, XRD, and dissolution studies. The prepared solid dispersions showed excellent improvement of drug solubility due to mean drug particle size reduction which lead to increase drug dissolution and bioavailability
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