Abstract
Transdermal patches are a cutting-edge drug delivery technology that is essential in the management of many disorders. As first-pass metabolism is avoided, TDDS can effectively increase bioavailability and aid in the delivery of drug molecules into the systemic circulation at a planned and controlled rate. This study's goal was to create matrix-type simvastatin transdermal patches utilising the solvent evaporation method and various polymer ratios, including HPMC 15 cps, HPMC E5, and Eudragit S 100. Plasticizers like glycerine, propylene glycol, and PEG 200 are utilised, along with solvents like methanol and chloroform. According to FTIR studies, pure drugs and excipients are compatible with each other. The tested patches are assessed for thickness, weight variation, folding endurance, moisture content, drug content, surface pH, and in vitro diffusion studies. The results indicated that the formulation F5 showed better characteristic properties and in vitro drug diffusion.
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