Formulation and Evaluation of Rizatriptan Matrix Tablet

Abstract

Mucoadhesive polymer owing to its binding capacity with gastric mucin prolongs the gastric residence time and thereby increases bioavailability. In the present research work an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Rizatriptan. Matrix tablets were prepared by direct compression technology using different types and levels of polymers viz. HPMC K15M, carbopol 934P, ethyl cellulose etc alone and in combinations. Compressed tablets were evaluated for thickness, friability, hardness, uniformity of weight, content of active ingredient, swelling and in vitro dissolution studies. The studies indicated that the drug release can be modulated by varying the concentrations of polymers. It was observed that combination of both the polymers in equal concentration exhibited the best release profile and able to sustain the drug release for 10h. Kinetic studies were also carried out on different formulations which showed that formulation RF1, RF2, RF3, RF7, RF8 and RF10 followed zero order while RF4, RF5, RF6 and RF10 followed first order release kinetics. According to Korsmeyer Peppas, RF1, RF2,RF3, RF7,RF8,R F9 and R F10 showed non fickian diffusion. While RF4, RF5 and R F6 followed fickian diffusion. Stability studies revealed that all the formulation was found to be stable under accelerated stability studies.