Formulation and evaluation of ranitidine floating tablet

Abstract

The aim of present investigation is to formulate floating tablet to increase duration of action of ranitidine. Floating tablet of ranitidine has long duration of action as compare to its sustained release formulation, Floating tablet has double duration of action than sustained release formulation. Floating tablet is developed by using various polymers like HPMC (15000) and few grades of carbopol, citric acid and sodium bicarbonate were added for effervescence. Tablets were prepared by wet granulation technique by using single operation punch machine in different formulation with polymers, also included testing of some physical parameters like swelling index , hardness and weight variations. In vitro buoyancy evaluation was carried-out and in vitro release of drug was also performed. Increase in quantity of effervescence did not affect buoyancy while facilitating the release of drug. In-Vitro drug release increased when increased quantity of polymers like HPMC and carbopol.