Formulation and evaluation of raft forming pirenzepine dihydrochloride floating tablets for peptic ulcer

Abstract

Objective: Over past few decades, Peptic ulcer disease remains a common condition despite the lots of novelty in treatment. The objective of this research work was to formulate gastro retentive floating tablet by raft approach using Pirenzepine dihydrochloride (PNZ) as drug candidate. Formulation also contained a raft forming agent (sodium alginate) along with alkalizing agents (Calcium carbonate and Sodium Bicarbonate). Raft strength was only affected by the amount of Raft forming agent, Calcium carbonate and Sodium Bicarbonate . Method: Tablets were prepared by direct compression method and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and In vitro drug release. Experimental work: A Box Behnken design was used in present study for optimization. Amount of gel forming agent, amount of cross-linkingagentsand floating agent were selected as independent variables. Raft strength, Acid neutralization capacity, and drug release were selected as dependent variables. Result:Raft strength, Acid neutralization capacity and In vitro drug release of all the experimental batches were found to be satisfactory. F10 batch was optimized based on maximum raft strength, good acid neutralization capacity and control drug release. Drug-excipients compatibility study showed no interaction between drug and excipients.