Formulation and Evaluation of Pulsatile Drug Delivery System of Atenolol

Sudipta Das,Baishali Ghosh,Surita Basu

doi:10.51152/jbarbiomed.v6i1.8

Abstract

The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation press coated by using different weight ratios of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / both HPMC and EC. The optimum result was achieved in formulation containing HPMC: EC weight ratios. The F3 batch achieved a highest burst release after the lag time which is applicable pulsatile drug delivery system of Atenolol.

Highlights

Oral drug delivery system is the fast growing, largest and the oldest segment of the total drug delivery market
PREPARATION OF PRESS COATED TABLETS:( Keraliya et al,2014) The core tablets were compressed coated with 340 mg of coating material containing different weight ratios (w/w) of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / HPMC: EC
Evaluation of tablets: WEIGHT VARIATION:(Fukui et al,2000) Twenty tablets were randomly selected from each batch individually

Summary

Introduction

Oral drug delivery system is the fast growing, largest and the oldest segment of the total drug delivery market. Over the past two decades, the pharmaceutical market has been demonstrating increased prefer ability for controlled and targeted drug delivery system. Such system has been focused on constant, variable; sustain drug release delivery system targeting the therapeutic agent to specific site/organ (Sadaphal et al, 2011). Studies have revealed that disease has a predictable cyclic rhythm and that the timing of medication regimens can improve the outcome of a desired effect This condition demands release of drug as a “pulse” after a lag time and has to be designed in such a way that a complete and rapid drug release should follow lag time. Such systems are called pulsatile drug delivery system (Survase et al, 2007)

Objectives

Methods

Results

Conclusion