Abstract
Proliposomes were successfully formulated using film deposition on carrier technique and characterized for percentage yield, drug content, size, PDI, zeta potential, flow properties, TEM, and in vitro drug release. Proliposome tablet was prepared by directly compressing the powder and evaluated for general appearance, weight variation, thickness, diameter, hardness, friability, disintegration time, in-vitro dissolution, assay, in-vivo gastric damage study, liposome size after reconstitution, pharmacokinetic study and stability study. Percentage yield and drug content of proliposome powder were found to be 95.10% and 91.54% respectively. Vesicular Size, PDI, zeta potential and entrapment efficiency of liposomes were found to be 231 nm, 0.477, −25.0 mV and 68.02% respectively. Diclofenac sodium loaded proliposome tablet showed 1.95 times higher bioavailability compared to plain enteric coated tablet of Diclofenac sodium. In vivo gastric damage study indicated that prepared Diclofenac sodium loaded proliposome tablets exhibited higher bioavailability and was safer compared to plain drug.
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