Formulation and Evaluation of Phyto-phospholipid complex of Methanolic Extract of leaves of Andrographis paniculate

Abstract

Andrographis paniculata is widely used plant in Southeast Asia, China and India as a healthy food, it contains andrographolide as a pharmacologically active constituent isolated from leaves and roots of Andrographis paniculata and has got wide therapeutic potential including anti-inflammatory, antiviral and hepatoprotective activity but its bioavailability is limited due to its poor solubility, rapid clearance rate and high plasma protein binding. Several attempts involving formulation of liposomes, noisome, nanoparticles, micro emulsions and solid lipid nanoparticle have been done to perk up its solubility and hence bioavailability. The aim of the proposed work is to formulate Phytosomes of methanolic extract of leaves of Andrographis paniculate. The Phytosomes were formulated using thin film hydration technique with varying molar ratios of phospholipid and extract of leaves of Andrographis paniculate. Formulated Phytosomes were characterized for particle size and size distribution, entrapment efficiency, in-vitro drug release characteristics, scanning electron microscopy and FTIR analysis.