Formulation and evaluation of phenylephrine and amikacin nanoemulsion

Abstract

The central perspective of this study is to formulate phenylephrine, and Amikacin loaded nanoemulsion by designing a pseudo ternary phase method. Selection of oils (castor oil, captex 200, ethyl oleate, triacetin) was made on the bases of the solubility studies. Captex 200 was chosen as the ideal oil phase for the formulation of emulsion due to its high solubility of both the drugs 1e., 106.54±3.84 mg/ml and 116.32±2.72mg/ml. The formulated Nanoemuslion was evaluated for thermodynamic stability, phase separation, transmission studies, percentage drug content, zeta potential(mV), Polydispersity index (PI) and particle size(nm). Among nine formulations of nanoemulsion, S6 formulation shows better and desired results like 95.27 ± 1.66% of drug content; 154.7nm of Particle size; 0.264 of PI and -44.5mV of zeta potential. Form the data. It was concluded that the reduction in particle size of S6 nanoemulsion might play a significant role in the enhancement of bioavailability of phenylephrine and Amikacin.